Isis@Mach Italia is a multidisciplinary project that networks a wide range of Italian scientific instruments and the skills of the researchers who use and manage them. The infrastructure offers, through competitive calls and peer-review processes, access to this instrumentation with the support of the associated researchers, for the performance of analyses of samples or materials to researchers in teams, with at least one Italian member, both from academia and the business world. Launched in 2020, IM@IT has already attracted over a hundred users, with participants in the calls doubling in recent years. The Milano-Bicocca unit is coordinated by the Department of Physics and involves a dozen instruments spread across Science and Medicine.